From Chapter 3:
Another tract which may be classed with Venner's "Treatise" was the "Nepenthes or the Vertues of tobacco," by Dr. William Barclay, which was published at Edinburgh in 1614. This is sometimes referred to and quoted, as by Fairholt, as if it were a whole-hearted defence of tobacco-taking. But Barclay enlarges mainly on the medicinal virtues of the herb. "If Tabacco," he says, "were used physically and with discretion there were no medicament in the worlde comparable to it"; and again: "In Tabacco there is nothing which is not medicine, the root, the stalke, the leaves, the seeds, the smoake, the ashes." The doctor gives sundry directions for administering tobacco—"to be used in infusion, in decoction, in substance, in smoke, in salt." But Barclay clearly does not sympathize with its indiscriminate use for pleasure. "As concerning the smoke," he says, "it may be taken more frequently, and for the said effects, but always fasting, and with emptie stomack, not as the English abusers do, which make a smoke-boxe of their skull, more fit to be carried under his arme that selleth at Paris dunoir a noircir to blacke mens shooes then to carie the braine of him that can not walke, can not ryde except the Tabacco Pype be in his mouth." He goes on to say that he was once in company with an English merchant in Normandy—"betweene Rowen and New-haven"—who was a merry fellow, but was constantly wanting a coal to kindle his tobacco. "The Frenchman wondered and I laughed at his intemperancie."

From Chapter 8:
In the whole sixteen volumes of Walpole's correspondence, as so admirably edited by Mrs. Toynbee, there is scarcely a mention of tobacco; and the same may be said of other collections of letters of the same period—the Selwyn letters, the Delany correspondence, and so on. Neither Walpole nor any member of the world in which he lived would appear to have smoked. In Miss Burney's "Evelina," 1778, from the beginning to the end of the book there is no mention whatever of tobacco or of smoking. Apparently the vulgar Branghtons were not vulgar enough to smoke. Such use of tobacco was considered low, and was confined to the classes of society indicated in the preceding chapter. One of the characters in Macklin's "Love à la Mode," 1760, is described as "dull, dull as an alderman, after six pounds of turtle, four bottles of port, and twelve pipes of tobacco."