From Chapter 4:
Among the documents in the possession of the Society of Antiquaries of Scotland there is a letter patent under the great seal of Charles I, in 1634, granted for the purpose of correcting the irregular sales and restraining the immoderate use of tobacco in Scotland. The letter states that tobacco was used on its first introduction as a medicine, but had since been so largely indulged in and was frequently of such bad quality, as not only to injure the health, but deprave the morals of the King's subjects. These were sentiments worthy of King James. Mr. Matthew Livingstone, who has calendared this document, says that the King therein proceeds, in order to prevent such injurious results of the use of tobacco, to appoint Sir James Leslie and Thomas Dalmahoy to enjoy for seven years the sole power of appointing licensed vendors of the commodity. These vendors, after due examination as to their fitness, were to be permitted, on payment of certain compositions and an annual rent in augmentation of the King's revenue, to sell tobacco in small quantities. The letter further directs that the licensees so appointed shall become bound to sell only sound tobacco—an admirable provision, if a trifle difficult to enforce—and to keep good order in their houses and shops. "The latter clause," adds Mr. Livingstone, "would almost suggest that the tobacco was to be sold for consumption on the premises,"—as I have no doubt it was—"and that the smokers were probably in the habit at their symposiums of using, even as they may still, I dare say, other indulgences not so soothing in their effects as the coveted weed"—a suggestion for which there seems little foundation in the clause to which Mr. Livingstone refers.

From Chapter 5:
The belief in the prophylactic power of tobacco was, however, very generally held. When Mr. Samuel Pepys on June 7, 1665, for the first time saw several houses marked with the ominous red cross, and the words "Lord, have mercy upon us" chalked upon the doors, he felt so ill at ease that he was obliged to buy some roll tobacco to smell and chew. There is nothing to show that Pepys even smoked, which considering his proficiency in the arts of good-fellowship, is perhaps a little surprising. Defoe, in his fictitious but graphic "Journal of the Plague Year in London," says that the sexton of one of the London parishes, who personally handled a large number of the victims, never had the distemper at all, but lived about twenty years after it, and was sexton of the parish to the time of his death. This man, according to Defoe, "never used any preservative against the infection other than holding garlic and rue in his mouth, and smoking tobacco."