From Chapter 4:
On weekdays many New England Puritans probably smoked as their friends in old England did. A contemporary painting of a group of Puritan divines over the mantelpiece of Parson Lowell, of Newbury, shows them well provided with punch-bowl and drinking-cups, tobacco and pipes. One parson, the Rev. Mr. Bradstreet, of the First Church of Charlestown, was very unconventional in his attire. He seldom wore a coat, "but generally appeared in a plaid gown, and was always seen with a pipe in his mouth." John Eliot, the noble preacher and missionary to the Indians, warmly denounced both the wearing of wigs and the smoking of tobacco. But his denunciations were ineffectual in both matters—heads continued to be adorned with curls of foreign growth, and pipe-smoke continued to ascend.

From Chapter 5:
Among the many medicinal virtues attributed to tobacco was its supposed value as a preservative from contagion at times of plague. Hearne, the antiquary, writing early in 1721, said that he had been told that in the Great Plague of London of 1665 none of those who kept tobacconists' shops suffered from it, and this belief no doubt enhanced the medical reputation of the weed. I have also seen it stated that during the cholera epidemics of 1831, 1849, and 1866 not one London tobacconist died from that disease; but good authority for the statement seems to be lacking. Hutton, in his "History of Derby," says that when that town was visited by the plague in 1665, that at the "Headless-cross ... the market-people, having their mouths primed with tobacco as a preservative, brought their provisions.... It was observed, that this cruel affliction never attempted the premises of a tobacconist, a tanner or a shoemaker." Whatever ground there may have been for the belief in the prophylactic effect of smoking, there can be no doubt that in the seventeenth century it was firmly held. Howell in one of his "Familiar Letters" dated January 1, 1646, says that the smoke of tobacco is "one of the wholesomest sents that is against all contagious airs, for it overmasters all other smells, as King James they say found true, when being once a hunting, a showr of rain drave him into a Pigsty for shelter, wher he caus'd a pipe full to Be taken of purpose." But here Mr. Howell is certainly drawing the long-bow. One cannot imagine the author of the "Counterblaste" countenancing the use of tobacco under any circumstances.